產(chǎn)品屬性：
產(chǎn)品名稱 | iFSP1 |
規(guī)格 | 5mg、10mg、50mg、100mg |
貨號 | EY-01Y16048 |
Cas No.: 150651-39-1
別名: N/A
化學(xué)名: 1-amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
分子式: C20H13N5
分子量: 323.4
溶解度: 1mg/mL in ethanol, 25mg/mL in DMSO, 30mg/mL in DMF
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
iFSP1 is an inhibitor of apoptosis inducing factor mitochondria-associated 2/ferroptosis suppressor protein 1 (AIFM2/FSP1).[1] It decreases cell viability in wild-type, but not glutathione peroxidase 4 (GPX4) knock-out, Pfa1 and HT1080 cells overexpressing AIFM2/FSP1, an effect that can be blocked by the ferroptosis inhibitor liproxstatin-1 . iFSP1 (3 μM) sensitizes a variety of human cancer cell lines to the ferroptosis inducer (1S,3R)-RSL3 .
特別提醒公司產(chǎn)品僅供科研使用
