產(chǎn)品屬性：
產(chǎn)品名稱 | bpV(phen) (potassium hydrate) |
規(guī)格 | 5mg、25mg |
貨號(hào) | EY-01Y16466 |
Cas No.: 171202-16-7
別名: N/A
化學(xué)名: N/A
分子式: C12H8N2O5V?K+(H2O)3
分子量: 404.3
溶解度: DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 343 nM), and PTP-1β (IC50 = 920 nM). At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.
特別提醒公司產(chǎn)品僅供科研使用
