產(chǎn)品屬性：
產(chǎn)品名稱(chēng) | SM 324405 |
規(guī)格 | 10 mg、50 mg |
貨號(hào) | EY-01Y10429 |
Cas No.: 677773-91-0
別名: N/A
化學(xué)名: N/A
分子式: C19H23N5O4
分子量: 385.42
溶解度: DMSO: 100 mM
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Potent TLR7 agonist (EC50 = 50 nM). Exhibits selectivity for TLR7 over TLR8. Induces IFN-α and -γ expression in human PBMCs and mouse splenocytes, and inhibits IL-5 production in human PBMCs in vitro. Rapidly metabolized to acid metabolite (t? = 2.6 min in human plasma).Kurimoto et al (2010) Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. J.Med.Chem. 53 2964 PMID:20232824 |Biffen et al (2012) Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. Br.J.Pharmacol. 166 573 PMID:22122192
特別提醒公司產(chǎn)品僅供科研使用
