產品屬性：
產品名稱 | TBK1/IKKε-IN-1 |
規(guī)格 | 5mg、10mg、25mg |
貨號 | EY-01Y10832 |
Cas No.: 2058264-32-5
別名: N/A
化學名: N/A
分子式: C28H26N4O5
分子量: 498.53
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM.
TBK1|100 nM (IC50)|IKKε|100 nM (IC50)
IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response[1].[1]. Brian A. Sherer, et al. Tbk/ikk inhibitor compounds and uses thereof. US 20160376283 A1.
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