產(chǎn)品屬性：
產(chǎn)品名稱 | Pitavastatin lactone-d4 |
規(guī)格 | 500 μg、1 mg、5 mg |
貨號 | EY-01Y13201 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C25H18D4FNO3
分子量: 407.5
溶解度: Ethanol: soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Pitavastatin lactone-d4 is intended for use as an internal standard for the quantification of pitavastatin lactone by GC- or LC-MS. Pitavastatin lactone is a major phase 2 metabolite of the HMG-CoA reductase inhibitor pitavastatin .1,2 Pitavastatin lactone is formed when pitavastatin undergoes glucuronidation by the UDP-glucuronysyltransferase (UGT) isoforms UGT1A1, UGT1A3, or UGT2B7 to form pitavastatin glucuronide, which then undergoes non-enzymatic conversion to pitavastatin lactone. It can be retroconverted to pitavastatin via hydrolysis. 1.Fujino, H., Yamada, I., Shimada, S., et al.Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: Human UDP-glucuronosyltransferase enzymes involved in lactonizationXenobiotica33(1)27-41(2003)
2.Aoki, T., Nishimura, H., Nakagawa, S., et al.Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseArzneimittelforschung47(8)904-909(1997)
特別提醒公司產(chǎn)品僅供科研使用
