產品屬性：
產品名稱 | VP3.15 dihydrobromide |
規(guī)格 | 1mg、5mg |
貨號 | EY-01Y14157 |
Cas No.: 1281681-33-1
別名: N/A
化學名: N/A
分子式: C20H24Br2N4OS
分子量: 528.3
溶解度: DMSO: 62.5 mg/mL (118.30 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 dihydrobromide has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS)[1].IC50: 1.59 μM (PDE7), 0.88 μM (GSK-3)[1][1]. Medina-Rodríguez EM, et al. Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis. Sci Rep. 2017 Mar 3;7:43545.
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