產(chǎn)品屬性：
產(chǎn)品名稱(chēng) | Tyk2-IN-8 |
規(guī)格 | 100mg、250mg、500mg |
貨號(hào) | EY-01Y15275 |
Cas No.: 2127109-84-4
別名: N/A
化學(xué)名: N/A
分子式: C20H17N9
分子量: 383.41
溶解度: DMSO: 16.67 mg/mL (43.48 mM)
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis[1].IC50: 17 nM (TYK2 JH1)[1]Tyk2-IN-8 also inhibits JAK1 (IC50=74 nM) and JAK2 (IC50=383 nM)[1].[1]. Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18.
特別提醒公司產(chǎn)品僅供科研使用
