產(chǎn)品屬性：
產(chǎn)品名稱 | SJF620 hydrochloride |
規(guī)格 | 5 mg、10 mg、25 mg |
貨號(hào) | EY-01Y15494 |
Cas No.: N/A
別名: N/A
化學(xué)名: N/A
分子式: C41H45ClN8O7
分子量: 797.3
溶解度: N/A
儲(chǔ)存條件: Store at -20°C, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
SJF620 hydrochloride is a potent PROTAC BTK degrader with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN[1].SJF620 hydrochloride is a PROTAC that retains potent degradation of BTK in cellular assays with a DC50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA[1].SJF620 hydrochloride has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with the half life (t1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802[1].[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.
特別提醒公司產(chǎn)品僅供科研使用
