產品屬性：
產品名稱 | β-Muricholic Acid-d4 |
規(guī)格 | 1 mg |
貨號 | EY-01Y15649 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C24H36D4O5
分子量: 412.6
溶解度: DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
β-Muricholic acid-d4 (β-MCA-d4) is intended for use as an internal standard for the quantification of β-muricholic acid by GC- or LC-MS. β-MCA is a murine-specific primary bile acid.1,2 Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.3 Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.41.Eyssen, H.J., Parmentier, G.G., and Mertens, J.A.Sulfate bile acids in germ-free and conventional miceEur. J. Biochem.66(3)507-514(1976)
2.Wahlstr?m, A., Sayin, S.I., Marschall, H.-I., et al.Intestinal crosstalk between bile acids and microbiota and its impact on host metabolismCell Metab.24(1)41-50(2016)
3.Fujino, Y., Nakayama, K., Yoshimura, K., et al.Suppression of hepatic HMG-CoA reductase activity by β-muricholic acid in mice fed a diet containing cholesterol and cholic acidJpn. J. Pharmacol.46(4)421-423(1988)
4.Wang, D.Q.-H., and Tazuma, S.Effect of β-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J miceJ. Lipid. Res.43(11)1960-1968(2002)
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