產(chǎn)品屬性：
產(chǎn)品名稱 | H-Leu-OH |
規(guī)格 | 250g、100g |
貨號 | EY-01Y18076 |
Cas No.: 61-90-5
別名: N/A
化學(xué)名: (2S)-2-amino-4-methylpentanoic acid
分子式: C6H13NO2
分子量: 131.2
溶解度: N/A
儲存條件: Store at RT
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].L-Leucine (10 mM) treatment impairs endocrine progenitor cell development[1].In E13.5 rat pancreatic explants, in absence of added L-Leucine, Ngn3 mRNA levels increased after 1 day of culture, peaked on day 3, and then decreased. When L-Leucine is added, a dramatic decrease is observed in Ngn3 mRNA levels. This decrease in Ngn3 mRNA levels was paralleled by a decrease in the number of Ngn3-expressing cells (4728±408 vs. 959±28; PNgn3, its target Insm1, and insulin[1]. Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation. L-Leucine increases intracellular HIF-1α levels and activates the HIF-1α signaling pathway, and these two effects are mediated by the mTOR signaling pathway. This process results in Ngn3 repression and, consequently, decreases β-cell differentiation[1].
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