產(chǎn)品屬性：
產(chǎn)品名稱 | Aquastatin A |
規(guī)格 | 500μg、2.5mg |
貨號 | EY-01Y19446 |
Cas No.: 153821-50-2
別名: N/A
化學(xué)名: N/A
分子式: C36H52O12
分子量: 676.8
溶解度:
儲存條件: -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Aquastatin A is a fungal metabolite originally isolated from F. aquaeductuum that has diverse biological activities.1 It is active against S. aureus (MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50 = 3.2 μM) and S. aureus fatty acid synthesis (IC50 = 3.5 μM).2 Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K., et al.Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological propertiesJ. Antibiot. (Tokyo)46(11)1648-1657(1993)
2.Kwon, Y.-J., Fang, Y., Xu, G.-H., et al.Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611Biol. Pharm. Bull.32(12)2061-2064(2009)
3.Seo, C., Soh, J.H., Oh, H., et al.Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060Bioorg. Med. Chem. Lett.19(21)6095-6097(2009)
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